ACTH protects against glucocorticoid-induced osteonecrosis of bone.
نویسندگان
چکیده
We report that adrenocorticotropic hormone (ACTH) protects against osteonecrosis of the femoral head induced by depot methylprednisolone acetate (depomedrol). This therapeutic response likely arises from enhanced osteoblastic support and the stimulation of VEGF by ACTH; the latter is largely responsible for maintaining the fine vascular network that surrounds highly remodeling bone. We suggest examining the efficacy of ACTH in preventing human osteonecrosis, a devastating complication of glucocorticoid therapy.
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عنوان ژورنال:
- Proceedings of the National Academy of Sciences of the United States of America
دوره 107 19 شماره
صفحات -
تاریخ انتشار 2010